|
KMID : 0358320060470060601
|
|
Korean Journal of Urology
2006 Volume.47 No. 6 p.601 ~ p.606
|
|
|
Optimal Size Cutoff Point for Prognostic Stratification of Localized Renal Cell Carcinoma
|
|
Lee Dong-Gi
Chang Sung-Goo
Jeon Seung-Hyun
|
|
|
Abstract
|
|
|
Purpose: The purpose of this study was to evaluate the validity of the cutoff size for a localized renal cell carcinoma(RCC) by assessing the survival of RCC patients according to a series of alternative size cutoff values.
Materials and Methods: The outcomes of 147 patients with localized RCC, treated by radical nephrectomy at our institution, between 1984 and 2004, were retrospectively evaluated. The mean follow-up period was 54.9±32.5 months. The survival of patients with tumors smaller than a specified size cutoff was compared with that of tumors larger than the cutoff, and the most discriminating cutoff identified.
Results: 114 and 33 patients were pT1(77.6%) and pT2(22.4%), respectively. There were 10 recurrences(8.8%) and 6 deaths(5.3%) in the pT1 group, and 8 recurrences(24.2%) and 8 deaths(24.2%) in the pT2 group. The differences in survival were maximized when the tumor size cutoff point was 7cm(cancer-specific survival rate: 92.0% vs. 71.5% p=0.0003, diseasefree survival rate: 88.5% vs. 69.1% p=0.0092). The next significant difference was observed with a cutoff of 4cm(cancer-specific survival rate: 96.0% vs. 83.7% p=0.0467, disease-free survival rate: 96.0% vs. 78.8% p= 0.0121).
Conclusions: Tumor size is an important prognostic factor in patients with an organ confined RCC. The established cutoff point of 7cm provided reasonable prognostic differences. A 4cm cutoff point is also feasible for separating groups with different survivals after a nephrectomy. Hence, the T1a/1b/T2 classification system is practical for the division of localized RCC. (Korean J Urol 2006;47:601-606)
|
|
|
KEYWORD
|
|
|
Renal cell carcinoma, Neoplasm staging, Neoplasms
|
|
|
FullTexts / Linksout information
|
|
  
|
|
|
Listed journal information
|
|
  
|